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In contrast, shorter-acting GLP-1RAs such as exenatide are rapidly cleared and do not maintain chronic receptor occupation

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Participating NRAs are TGA, FDA, Health Canada, HSA, Swissmedic, ANVISA (Brazil), MHRA and Israel

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Although -oxidation is impaired in the setting of VPA toxicity, this metabolite has a prolonged elimination half-life and could be responsible for the prolonged coma that is sometimes observed despite the normalization in plasma VPA concentrations [17, 18]